Chapter 29

Fig. 29.8 Overlay of the crystal structures of the AT1 receptor with the bound octapeptide angiotensin II 29.20 (yellow, inner surface yellow, outside red) and the low molecular weight sartan-like ligand 29.21 (green, inner surface green, outside blue). For crystallization, the receptor was stabilized with an antibody (not shown in the figure). The C-terminal acid function of 29.20 forms a hydrogen bond to Lys 199, and the tetrazole of 29.21 interacts with Arg 167. Structure determination suggests that the binding domains of angiotensin II and the sartans overlap spatially.