Chapter 29

Fig. 29.11 The crystal structure of erythropoietin (EPO) with the ligand-binding domain of the erythropoietin receptor (EPOR). The structural elements are represented schematically. EPO adopts a tetrahelical bundle folding pattern (yellow). The dimeric receptor is basically constructed from β-pleated sheets. The contact surface between receptor and ligand are shown in white and blue (interior side is yellow).