Fig. 32.1 Crystal structure of a complete IgG antibody. The two Fab regions form the left and right branches (red, green...
Fig. 32.2 Comparison of the crystal structures of two Fab domains that were released by proteolytic cleavage with papain...
Fig. 32.3 The contact surfaces with the bound antigens are shown for both of the Fab domains shown in Fig. 32.2. (a) The...
Fig. 32.6 Modifications are performed on the backbone of the oligonucleotide strand to reduce its polarity and increase ...
Fig. 32.8 Crystal structure of the HIV reverse transcriptase. The protein is made up of a p66 (purple) and a p51 (yellow...
Fig. 32.9 (a) Crystal structure of reverse transcriptase with a covalently attached DNA strand. A thymidine-5′-triphos...
Fig. 32.10 Nevirapine 32.19 was discovered as an allosteric inhibitor of reverse transcriptase in screening. The rigid m...
Fig. 32.12 DThe two triazines 32.25 and 32.26 block the allosteric binding site of HIV reverse transcriptase. Surprising...
Fig. 32.13 Crystal structure of the topoisomerase (topo IV from Streptococcus pneumoniae, gray ribbon model) with two ol...
Fig. 32.15 Crystal structures of the Tet repressor with a bound DNA sequence segment (left). On the right, the tetracycl...
Fig. 32.19 View of the human mitochondrial ribosome based on a cryo-EM structure. RNA parts are shown in white/gray, pro...
Fig. 32.21 View of the human mitochondrial ribosome based on a cryo-EM structure. RNA parts are shown in white/gray, pro...
Fig. 32.22 The binding sites of dalfopristin 32.40 and quinupristin 32.41 are in close proximity to the peptidyl transfe...