Fig. 27.3 The stereochemically unambiguous transfer of a hydride ion from the NADPH cofactor to the double bond of the s...
Fig. 27.4 In most NAD(P)H-dependent enzymes, the cofactor binds to the so-called Rossmann fold in a structurally conserv...
Fig. 27.7 Fluconazole 27.6 is an antimycotic and blocks the sixth coordination site on the iron ion of a cytochrome P450...
Fig. 27.14 The crystal structure determination of HMG-CoA reductase was accomplished with the bound NADPH cofactor (gree...
Fig. 27.15 Superposition of the structures of HMG-CoA reductase in complex with simvastatin 27.30 (gray) and atorvastati...
Fig. 27.19 Crystal structures of aldose reductase with (a) sorbinil 27.50, (b) tolrestat 27.44, (c) IDD594 27.48, and (d...
Fig. 27.20 Crystallographically determined binding geometry of sorbinil 27.50 to aldose reductase. The inhibitor’s hyd...
Fig. 27.24 Crystal structure of human 11β-HSD1 with carbenoxolone 27.60 (gray). The inhibitor binds competitively to co...
Fig. 27.25 Crystallographically determined binding geometries of the inhibitors 27.62 (beige) and 27.63 (gray) together ...
Fig. 27.27 Crystal structures of human CYP 3A4 in an uncomplexed state (a), with bound metyrapone 27.8 (b), with erythro...
Fig. 27.33(a) Crystal structure of MAOB in complex with covalently bound tranylcypromine 27.75. The inhibitor is attache...
Fig. 27.34 MAOA (a) and MAOB (b) differ in the binding region of the biogenic amine. The shape of the binding pocket is ...
Fig. 27.39 Superposition of arachidonic acid 27.86 (violet) and PGH2 27.88 (gray) in the reaction channel of COX. The he...
Fig. 27.41The most probable binding mode of acetylsalicylic acid (ASA) 27.94 with COX-1. ASA binds in the middle of the ...
Fig. 27.42 Structure of celecoxib 27.101 with COX-2. The inhibitor is shown with a green surface (interior is blue). Pos...