Fig. 25.2 A crystal structure of MMP-12 with both cleavage products has been determined (Fig. 25.1c). The cleavage produ...
Fig. 25.5 The 3D structure of a complex of thermolysin and Cbz–GlyP –Leu–Leu 25.4 (gray carbon atoms). The leucine...
Fig. 25.6 The crystal structure of the carboxypeptidase–benzylsuccinate complex. A carboxylate group binds to the zinc...
Fig. 25.12 Crystal structure of lisinopril 25.19 (Fig.25.11) with t-ACE. The central carboxylate group of the inhibitor ...
Fig. 25.14 Crystal structure of Ro 31-4724 (25.35, IC50 = 9 nM) and collagenase; the binding mode is shown. The hydroxam...
Fig. 25.16 Crystal structure of the collagenase MMP-1 with two different inhibitors 25.49 and 25.50. Because of a confor...
Fig. 25.17 The catalytic site in α-carbonic anhydrases is found at the end of a funnel-shaped binding pocket. There an ...
Fig. 25.20 Crystal structure of sildenafil 25.69 (Fig.25.21) in PDE 5. The pyrazolopyrimidinone moiety of the inhibitor ...
Fig. 25.22 Crystal structure of actinonin 25.75 with the peptide deformylase from Escherichia coli. The peptidic inhibit...