Fig. 21.2 The crystal structure of TGT with a portion of the tRNA. The protein adopts a TIM-barrel fold. The tRNA binds ...
Fig. 21.6 Crystal structure of TGT with 21.3, the first hit from LUDI (left). The agreement between prediction and subse...
Fig. 21.10 From the 6-amino-quinazolinone scaffold 21.12, the listed derivatives could be synthesized and tested by addi...
Fig. 21.16 The crystal structures with the 4-substituted lin-benzoguanine derivatives show that the basic nitrogen in th...
Fig. 21.18: The enzyme TGT forms a 2:1 complex with tRNA (top right). One monomer (dark blue, 1) catalyzes the base exch...
Fig. 21.19: Results of a hot-spot analysis of the contact area covering more than 1600 Å2. The stability contributions ...
Fig. 21.20 (a) Since the catalytic center and the flexible loop-helix motif (bottom left: orange, shown in different con...
Fig. 21.26 (a) (a) Structure of the functionally active homodimer of TGT. In the aromatic cluster, Tyr 330 has been repl...
Fig. 21.30 Upper left (a) shows an overlay of the binding modes of 21.21, 21.38 and 21.39 with TGT. The latter two ligan...